Results
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PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER. [electronic resource] by
- Vang, Amanda G
- Ben-Sasson, Shlomo Z
- Dong, Hongli
- Kream, Barbara
- DeNinno, Michael P
- Claffey, Michelle M
- Housley, William
- Clark, Robert B
- Epstein, Paul M
- Brocke, Stefan
Producer: 20101104
In:
PloS one vol. 5
Availability: No items available.
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4.
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Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders. [electronic resource] by
- Verhoest, Patrick R
- Fonseca, Kari R
- Hou, Xinjun
- Proulx-Lafrance, Caroline
- Corman, Michael
- Helal, Christopher J
- Claffey, Michelle M
- Tuttle, Jamison B
- Coffman, Karen J
- Liu, Shenpinq
- Nelson, Frederick
- Kleiman, Robin J
- Menniti, Frank S
- Schmidt, Christopher J
- Vanase-Frawley, Michelle
- Liras, Spiros
Producer: 20130226
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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5.
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Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors. [electronic resource] by
- Claffey, Michelle M
- Helal, Christopher J
- Verhoest, Patrick R
- Kang, Zhijun
- Fors, Kristina S
- Jung, Stanley
- Zhong, Jiaying
- Bundesmann, Mark W
- Hou, Xinjun
- Lui, Shenping
- Kleiman, Robin J
- Vanase-Frawley, Michelle
- Schmidt, Anne W
- Menniti, Frank
- Schmidt, Christopher J
- Hoffman, William E
- Hajos, Mihaly
- McDowell, Laura
- O'Connor, Rebecca E
- Macdougall-Murphy, Mary
- Fonseca, Kari R
- Becker, Stacey L
- Nelson, Frederick R
- Liras, Spiros
Producer: 20130226
In:
Journal of medicinal chemistry vol. 55
Availability: No items available.
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6.
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Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. [electronic resource] by
- Dounay, Amy B
- Anderson, Marie
- Bechle, Bruce M
- Campbell, Brian M
- Claffey, Michelle M
- Evdokimov, Artem
- Evrard, Edelweiss
- Fonseca, Kari R
- Gan, Xinmin
- Ghosh, Somraj
- Hayward, Matthew M
- Horner, Weldon
- Kim, Ji-Young
- McAllister, Laura A
- Pandit, Jayvardhan
- Paradis, Vanessa
- Parikh, Vinod D
- Reese, Matthew R
- Rong, SuoBao
- Salafia, Michelle A
- Schuyten, Katherine
- Strick, Christine A
- Tuttle, Jamison B
- Valentine, James
- Wang, Hong
- Zawadzke, Laura E
- Verhoest, Patrick R
Producer: 20140605
In:
ACS medicinal chemistry letters vol. 3
Availability: No items available.
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7.
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Discovery of a novel Kv7 channel opener as a treatment for epilepsy. [electronic resource] by
- Davoren, Jennifer E
- Claffey, Michelle M
- Snow, Sheri L
- Reese, Matthew R
- Arora, Gaurav
- Butler, Christopher R
- Boscoe, Brian P
- Chenard, Lois
- DeNinno, Shari L
- Drozda, Susan E
- Duplantier, Allen J
- Moine, Ludivine
- Rogers, Bruce N
- Rong, SuoBao
- Schuyten, Katherine
- Wright, Ann S
- Zhang, Lei
- Serpa, Kevin A
- Weber, Mark L
- Stolyar, Polina
- Whisman, Tammy L
- Baker, Karen
- Tse, Karen
- Clark, Alan J
- Rong, Haojing
- Mather, Robert J
- Lowe, John A
Producer: 20160620
In:
Bioorganic & medicinal chemistry letters vol. 25
Availability: No items available.
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8.
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Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator. [electronic resource] by
- Zhang, Lei
- Balan, Gayatri
- Barreiro, Gabriela
- Boscoe, Brian P
- Chenard, Lois K
- Cianfrogna, Julie
- Claffey, Michelle M
- Chen, Laigao
- Coffman, Karen J
- Drozda, Susan E
- Dunetz, Joshua R
- Fonseca, Kari R
- Galatsis, Paul
- Grimwood, Sarah
- Lazzaro, John T
- Mancuso, Jessica Y
- Miller, Emily L
- Reese, Matthew R
- Rogers, Bruce N
- Sakurada, Isao
- Skaddan, Marc
- Smith, Deborah L
- Stepan, Antonia F
- Trapa, Patrick
- Tuttle, Jamison B
- Verhoest, Patrick R
- Walker, Daniel P
- Wright, Ann S
- Zaleska, Margaret M
- Zasadny, Kenneth
- Shaffer, Christopher L
Producer: 20140415
In:
Journal of medicinal chemistry vol. 57
Availability: No items available.
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9.
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Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates. [electronic resource] by
- Stepan, Antonia F
- Claffey, Michelle M
- Reese, Matthew R
- Balan, Gayatri
- Barreiro, Gabriela
- Barricklow, Jason
- Bohanon, Michael J
- Boscoe, Brian P
- Cappon, Gregg D
- Chenard, Lois K
- Cianfrogna, Julie
- Chen, Laigao
- Coffman, Karen J
- Drozda, Susan E
- Dunetz, Joshua R
- Ghosh, Somraj
- Hou, Xinjun
- Houle, Christopher
- Karki, Kapil
- Lazzaro, John T
- Mancuso, Jessica Y
- Marcek, John M
- Miller, Emily L
- Moen, Mark A
- O'Neil, Steven
- Sakurada, Isao
- Skaddan, Marc
- Parikh, Vinod
- Smith, Deborah L
- Trapa, Patrick
- Tuttle, Jamison B
- Verhoest, Patrick R
- Walker, Daniel P
- Won, Annie
- Wright, Ann S
- Whritenour, Jessica
- Zasadny, Kenneth
- Zaleska, Margaret M
- Zhang, Lei
- Shaffer, Christopher L
Producer: 20171016
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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