Heavy and light chain variable single domains of an anti-DNA binding antibody hydrolyze both double- and single-stranded DNAs without sequence specificity. [electronic resource]
Producer: 20060807Description: 15287-95 p. digitalISSN:- 0021-9258
- Amino Acid Substitution
- Animals
- Antibodies, Antinuclear -- chemistry
- Base Sequence
- Crystallography, X-Ray
- DNA -- genetics
- DNA, Single-Stranded -- genetics
- Humans
- Hydrolysis
- Immunoglobulin Fragments -- chemistry
- Immunoglobulin Heavy Chains -- chemistry
- Immunoglobulin Light Chains -- chemistry
- In Vitro Techniques
- Kinetics
- Mice
- Mice, Inbred MRL lpr
- Models, Molecular
- Mutagenesis, Site-Directed
- Protein Conformation
- Protein Structure, Tertiary
- Recombinant Proteins -- chemistry
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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