Chemical Inhibition of Human Thymidylate Kinase and Structural Insights into the Phosphate Binding Loop and Ligand-Induced Degradation. [electronic resource]
Producer: 20170608Description: 9906-9918 p. digitalISSN:- 1520-4804
- Animals
- Binding Sites -- drug effects
- Calorimetry
- Cell Line
- Cell Survival -- drug effects
- Crystallography, X-Ray
- Dose-Response Relationship, Drug
- Humans
- Mice
- Models, Molecular
- Molecular Structure
- Nucleoside-Phosphate Kinase -- antagonists & inhibitors
- Phosphates -- metabolism
- Protein Kinase Inhibitors -- chemical synthesis
- Proteolysis -- drug effects
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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