Diarctigenin, a lignan constituent from Arctium lappa, down-regulated zymosan-induced transcription of inflammatory genes through suppression of DNA binding ability of nuclear factor-kappaB in macrophages. [electronic resource]
Producer: 20081113Description: 393-401 p. digitalISSN:- 1521-0103
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Arctium -- chemistry
- Cells, Cultured
- Cytokines -- genetics
- DNA -- metabolism
- Dinoprostone -- biosynthesis
- Female
- Gene Expression Regulation -- drug effects
- Interleukin-6 -- genetics
- Lignans -- pharmacology
- Lipopolysaccharides -- pharmacology
- Macrophages -- metabolism
- Mice
- Mice, Inbred C57BL
- NF-kappa B -- antagonists & inhibitors
- Nitric Oxide -- biosynthesis
- Nitric Oxide Synthase Type II -- genetics
- Promoter Regions, Genetic
- Signal Transduction -- drug effects
- Tumor Necrosis Factor-alpha -- genetics
- Zymosan -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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