The neuroblastoma tumour-suppressor TrkAI and its oncogenic alternative TrkAIII splice variant exhibit geldanamycin-sensitive interactions with Hsp90 in human neuroblastoma cells. [electronic resource]
Producer: 20091201Description: 4075-94 p. digitalISSN:- 1476-5594
- Alternative Splicing
- Antigens, Surface -- metabolism
- Benzoquinones -- pharmacology
- Enzyme Stability -- drug effects
- Genes, Tumor Suppressor -- drug effects
- HSP90 Heat-Shock Proteins -- metabolism
- Humans
- Isoenzymes -- metabolism
- Lactams, Macrocyclic -- pharmacology
- Neuroblastoma -- genetics
- Oncogenes -- drug effects
- Phosphorylation -- drug effects
- Protein Binding -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Protein Transport -- drug effects
- Receptor, trkA -- antagonists & inhibitors
- Transfection
- Tumor Cells, Cultured
- Tyrosine -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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