A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. [electronic resource]
Producer: 20071210Description: 21 p. digitalISSN:- 1742-2094
- Alzheimer Disease -- drug therapy
- Animals
- Behavior, Animal -- drug effects
- Brain -- drug effects
- Cytokines -- antagonists & inhibitors
- Disease Models, Animal
- Drugs, Investigational -- chemistry
- Humans
- Inflammation Mediators -- antagonists & inhibitors
- MAP Kinase Signaling System -- drug effects
- Mice
- Mice, Inbred C57BL
- Mitogen-Activated Protein Kinase 14 -- antagonists & inhibitors
- Protein Kinase Inhibitors -- chemistry
- Pyridazines -- chemistry
- Pyrimidines -- chemistry
- Synapses -- drug effects
- Up-Regulation -- drug effects
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Publication Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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