Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation. [electronic resource]
Producer: 20090820Description: 169-75 p. digitalISSN:- 1874-1754
- AMP-Activated Protein Kinases -- genetics
- Anti-Inflammatory Agents -- pharmacology
- Atherosclerosis -- drug therapy
- Cells, Cultured
- Endothelial Cells -- cytology
- Enzyme Activation -- drug effects
- Humans
- Hypoglycemic Agents -- pharmacology
- I-kappa B Kinase -- metabolism
- Interleukin-6 -- metabolism
- Metformin -- pharmacology
- NF-kappa B -- metabolism
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation -- drug effects
- RNA, Small Interfering
- Signal Transduction -- drug effects
- Tumor Necrosis Factor-alpha -- metabolism
- Umbilical Veins -- cytology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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