Deletion of P1 arginine in a novel antithrombin variant (antithrombin London) abolishes inhibitory activity but enhances heparin affinity and is associated with early onset thrombosis. [electronic resource]
Producer: 20030522Description: 13688-95 p. digitalISSN:- 0021-9258
- Age of Onset
- Antithrombin Proteins
- Antithrombins -- chemistry
- Arginine -- chemistry
- Binding, Competitive
- Blood Coagulation
- Chromatography, Affinity
- Chromatography, Liquid
- Electrophoresis, Polyacrylamide Gel
- Factor Xa Inhibitors
- Family Health
- Female
- Gene Deletion
- Heparin -- metabolism
- Heparitin Sulfate -- chemistry
- Heterozygote
- Humans
- Kinetics
- Male
- Models, Biological
- Pedigree
- Protein Binding
- Proteins -- genetics
- Thrombin -- antagonists & inhibitors
- Thrombosis -- etiology
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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