Fn14 overcomes cisplatin resistance of high-grade serous ovarian cancer by promoting Mdm2-mediated p53-R248Q ubiquitination and degradation. [electronic resource]
Producer: 20190816Description: 176 p. digitalISSN:- 1756-9966
- Animals
- Apoptosis -- genetics
- Cell Line, Tumor
- Cisplatin -- administration & dosage
- Drug Resistance, Neoplasm -- genetics
- Female
- Gene Expression Regulation, Neoplastic -- drug effects
- HSP90 Heat-Shock Proteins -- genetics
- Humans
- Mice
- Middle Aged
- Neoplasm Grading
- Ovarian Neoplasms -- drug therapy
- Progression-Free Survival
- Proteasome Endopeptidase Complex -- genetics
- Proteolysis
- Proto-Oncogene Proteins c-mdm2 -- genetics
- Signal Transduction -- drug effects
- TWEAK Receptor -- genetics
- Tumor Suppressor Protein p53 -- genetics
- Ubiquitination -- genetics
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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