Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity. [electronic resource]
Producer: 20150224Description: 5294-305 p. digitalISSN:- 1550-6606
- Antigen Presentation -- drug effects
- Atorvastatin
- B-Lymphocytes -- drug effects
- CD40 Antigens -- antagonists & inhibitors
- Dendritic Cells -- drug effects
- Gene Expression Regulation
- Heptanoic Acids -- pharmacology
- Humans
- Hydroxymethylglutaryl CoA Reductases -- genetics
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Immunity, Cellular -- drug effects
- Lymphocyte Activation -- drug effects
- Mevalonic Acid -- metabolism
- Primary Cell Culture
- Protein Prenylation -- drug effects
- Pyrroles -- pharmacology
- Signal Transduction
- Simvastatin -- pharmacology
- T-Lymphocytes -- drug effects
- Transcriptome -- immunology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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