In vivo efficacy of the AKT inhibitor ARQ 092 in Noonan Syndrome with multiple lentigines-associated hypertrophic cardiomyopathy. [electronic resource]
Producer: 20170919Description: e0178905 p. digitalISSN:- 1932-6203
- Alleles
- Aminopyridines -- pharmacology
- Animals
- Cardiomyopathy, Hypertrophic -- diagnostic imaging
- Cardiotonic Agents -- pharmacology
- Disease Models, Animal
- Echocardiography
- Gene Expression Regulation
- Humans
- Imidazoles -- pharmacology
- LEOPARD Syndrome -- diagnostic imaging
- Male
- Mice
- Mice, Transgenic
- Mutation
- Myocytes, Cardiac -- drug effects
- Phosphoproteins -- antagonists & inhibitors
- Protein Domains
- Protein Kinase Inhibitors -- pharmacology
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 -- genetics
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Signal Transduction
- TOR Serine-Threonine Kinases -- genetics
No physical items for this record
Publication Type: Journal Article
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