LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol. [electronic resource]
Producer: 20190422Description: 15867-15886 p. digitalISSN:- 1083-351X
- Actins -- metabolism
- Cytosol -- metabolism
- DNA-Binding Proteins
- Extracellular Matrix -- metabolism
- Fibroblasts -- metabolism
- Humans
- Idiopathic Pulmonary Fibrosis -- metabolism
- Lung -- metabolism
- Mechanotransduction, Cellular -- drug effects
- Membrane Proteins -- antagonists & inhibitors
- Nuclear Lamina -- metabolism
- Nuclear Proteins -- antagonists & inhibitors
- Peptide Fragments -- chemistry
- Phosphorylation
- Protein Phosphatase 2C -- metabolism
- Smad2 Protein -- antagonists & inhibitors
- Smad3 Protein -- antagonists & inhibitors
- Transforming Growth Factor beta -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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