Heme amplifies the innate immune response to microbial molecules through spleen tyrosine kinase (Syk)-dependent reactive oxygen species generation. [electronic resource]
Producer: 20101124Description: 32844-32851 p. digitalISSN:- 1083-351X
- Animals
- Cytokines -- immunology
- Dendritic Cells -- immunology
- Heme -- agonists
- Humans
- Immunity, Innate -- drug effects
- Intracellular Signaling Peptides and Proteins -- antagonists & inhibitors
- Lipopolysaccharides -- agonists
- Macrophages, Peritoneal -- immunology
- Mice
- Mice, Knockout
- NF-kappa B -- genetics
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphoinositide-3 Kinase Inhibitors
- Protein Kinase C -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Reactive Oxygen Species -- immunology
- Syk Kinase
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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