The RET receptor tyrosine kinase, but not its specific ligand, GDNF, is preferentially expressed by acute leukaemias of monocytic phenotype and is up-regulated upon differentiation. [electronic resource]
Producer: 19990610Description: 225-40 p. digitalISSN:- 0007-1048
- Bone Marrow Cells -- metabolism
- Cell Transformation, Neoplastic
- Glial Cell Line-Derived Neurotrophic Factor
- Humans
- Leukemia, Monocytic, Acute -- metabolism
- Nerve Growth Factors
- Nerve Tissue Proteins -- metabolism
- Phenotype
- Proto-Oncogene Mas
- RNA, Messenger -- metabolism
- Receptor Protein-Tyrosine Kinases -- metabolism
- Reverse Transcriptase Polymerase Chain Reaction -- methods
- Tumor Cells, Cultured
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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