Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. [electronic resource]
Producer: 20050407Description: 129-41 p. digitalISSN:- 1535-6108
- Animals
- Antineoplastic Agents -- pharmacology
- Benzamides
- Bone Marrow Cells -- cytology
- Cell Line
- Cell Line, Tumor
- Cell Survival
- Crystallography, X-Ray
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Fusion Proteins, bcr-abl -- antagonists & inhibitors
- Hematopoietic Stem Cells -- cytology
- Imatinib Mesylate
- Inhibitory Concentration 50
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy
- Mice
- Models, Biological
- Models, Chemical
- Mutation
- Mycoplasma -- metabolism
- Phosphorylation
- Piperazines -- pharmacology
- Precursor Cell Lymphoblastic Leukemia-Lymphoma -- drug therapy
- Pyrimidines -- chemistry
- Retroviridae -- genetics
- Time Factors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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