Discovery of a new binding site on human choline kinase α1: design, synthesis, crystallographic studies, and biological evaluation of asymmetrical bispyridinium derivatives. [electronic resource]
Producer: 20140401Description: 507-15 p. digitalISSN:- 1520-4804
- Antineoplastic Agents -- chemical synthesis
- Apoptosis
- Binding Sites
- Caspase 3 -- metabolism
- Cell Proliferation -- drug effects
- Choline Kinase -- antagonists & inhibitors
- Crystallography, X-Ray
- Drug Design
- Drug Screening Assays, Antitumor
- Enzyme Activation
- HeLa Cells
- Humans
- Molecular Docking Simulation
- Pyridines -- chemical synthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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