Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes. [electronic resource]
Producer: 20130610Description: 54-64 p. digitalISSN:- 1873-3344
- Antineoplastic Agents -- chemical synthesis
- Binding Sites
- Biological Transport
- Cell Line, Tumor
- Cell Survival -- drug effects
- Comet Assay
- Coordination Complexes -- chemical synthesis
- DNA -- chemistry
- DNA Cleavage -- drug effects
- DNA Topoisomerases, Type I -- chemistry
- Guanine -- analogs & derivatives
- Guanosine Monophosphate -- chemistry
- Humans
- Magnetic Resonance Spectroscopy
- Mannich Bases -- chemistry
- Molecular Structure
- Naphthoquinones -- chemical synthesis
- Platinum -- chemistry
- Topoisomerase I Inhibitors -- chemical synthesis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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