A chemical biology approach identifies a beta-2 adrenergic receptor agonist that causes human tumor regression by blocking the Raf-1/Mek-1/Erk1/2 pathway. [electronic resource]
Producer: 20070709Description: 3777-88 p. digitalISSN:- 0950-9232
- Adrenergic beta-2 Receptor Agonists
- Adrenergic beta-Agonists -- pharmacology
- Animals
- Apoptosis -- drug effects
- Blotting, Western
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cyclic AMP -- metabolism
- Ethanolamines -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- drug effects
- Female
- Guanine Nucleotide Exchange Factors -- drug effects
- Humans
- Immunohistochemistry
- In Situ Nick-End Labeling
- MAP Kinase Kinase 1 -- drug effects
- Mice
- Mice, Nude
- Neoplasms, Experimental -- drug therapy
- Proto-Oncogene Proteins c-raf -- drug effects
- Receptors, Adrenergic, beta-2 -- drug effects
- Signal Transduction -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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