The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors. [electronic resource]
Producer: 20041124Description: 42818-25 p. digitalISSN:- 0021-9258
- Adenosine Triphosphate -- chemistry
- Amino Acid Sequence
- Animals
- Baculoviridae -- metabolism
- Binding Sites
- COS Cells
- Catalytic Domain
- Cloning, Molecular
- Crystallography, X-Ray
- Dose-Response Relationship, Drug
- Drug Design
- Enzyme Inhibitors -- pharmacology
- Enzyme-Linked Immunosorbent Assay
- Fluorescence Resonance Energy Transfer
- Humans
- Models, Chemical
- Models, Molecular
- Molecular Sequence Data
- Peptides -- chemistry
- Protein Binding
- Protein Conformation
- Protein Folding
- Protein Structure, Tertiary
- Protein-Tyrosine Kinases -- antagonists & inhibitors
- Recombinant Proteins -- chemistry
- Sequence Homology, Amino Acid
- Staurosporine -- pharmacology
- Stereoisomerism
- Time Factors
- Transfection
- Tyrosine -- chemistry
- ZAP-70 Protein-Tyrosine Kinase
- src Homology Domains
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Publication Type: Journal Article
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