Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation. [electronic resource]
Producer: 20130814Description: 489-98 p. digitalISSN:- 1474-9726
- Animals
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cellular Senescence -- drug effects
- Culture Media, Conditioned
- Cytokines -- metabolism
- Enzyme Activation -- drug effects
- Fibroblasts -- drug effects
- Gene Expression -- drug effects
- Gene Expression Regulation
- Humans
- Hypoglycemic Agents -- pharmacology
- I-kappa B Kinase -- metabolism
- Inflammation -- genetics
- Lipopolysaccharides -- pharmacology
- Macrophages -- drug effects
- Male
- Metformin -- pharmacology
- Mice
- NF-kappa B -- metabolism
- Phosphorylation -- drug effects
- Prostatic Neoplasms
- RNA Interference
- RNA, Small Interfering
- Signal Transduction -- drug effects
- Transcription Factor RelA -- genetics
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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