N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison. [electronic resource]
Producer: 20040721Description: 3731-9 p. digitalISSN:- 0006-2960
- Acetaminophen -- metabolism
- Antigens, Neoplasm
- Antineoplastic Agents -- chemistry
- Benzoquinones -- chemistry
- Cell Line, Tumor
- Chromosome Breakage
- DNA Damage -- drug effects
- DNA Topoisomerases, Type I -- chemistry
- DNA Topoisomerases, Type II -- chemistry
- DNA-Binding Proteins
- Etoposide -- chemistry
- Humans
- Imines -- chemistry
- Mutagens -- chemistry
- Topoisomerase II Inhibitors
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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