2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead. [electronic resource]
Producer: 20071101Description: 4261-4 p. digitalISSN:- 0022-2623
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Peptides -- antagonists & inhibitors
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Aspartic Acid Endopeptidases -- antagonists & inhibitors
- CHO Cells
- Caco-2 Cells
- Cell Membrane Permeability
- Cricetinae
- Cricetulus
- Crystallography, X-Ray
- Humans
- Hydrogen Bonding
- Models, Molecular
- Molecular Conformation
- Mutation
- Oligopeptides -- chemistry
- Peptide Fragments -- antagonists & inhibitors
- Quinazolines -- chemical synthesis
- Rats
- Stereoisomerism
- Structure-Activity Relationship
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Publication Type: Journal Article
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