Simultaneously targeting CD45 significantly increases cytotoxicity of the anti-CD33 immunoconjugate, gemtuzumab ozogamicin, against acute myeloid leukemia (AML) cells and improves survival of mice bearing human AML xenografts. [electronic resource]
Producer: 20080716Description: 4813-6 p. digitalISSN:- 1528-0020
- Aminoglycosides
- Animals
- Antibodies -- pharmacology
- Antibodies, Monoclonal
- Antibodies, Monoclonal, Humanized
- Antigens, CD -- immunology
- Antigens, Differentiation, Myelomonocytic -- immunology
- Drug Interactions
- Gemtuzumab
- Humans
- Immunoconjugates
- Immunotherapy -- methods
- Leukemia, Myeloid, Acute -- therapy
- Leukocyte Common Antigens -- immunology
- Mice
- Sialic Acid Binding Ig-like Lectin 3
- Survival Rate
- Transplantation, Heterologous
- Tumor Burden -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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