Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter. [electronic resource]
Producer: 20040909Description: 7260-74 p. digitalISSN:- 0270-7306
- Base Sequence
- Breast Neoplasms -- genetics
- Cell Line, Tumor
- Cyclin D1 -- genetics
- Estrogen Receptor alpha
- Estrogens -- metabolism
- Female
- G1 Phase -- physiology
- Gene Expression Regulation
- Genes, Reporter
- Humans
- Macromolecular Substances
- Models, Genetic
- Progesterone -- metabolism
- Promoter Regions, Genetic
- Proto-Oncogene Proteins -- metabolism
- Proto-Oncogene Proteins c-fos -- metabolism
- Proto-Oncogene Proteins c-jun -- metabolism
- Receptors, Estrogen -- metabolism
- Repressor Proteins -- metabolism
- Response Elements
- Transcription Factors -- metabolism
- Transcription, Genetic
- Transcriptional Activation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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