Identification and SAR of novel diaminopyrimidines. Part 2: The discovery of RO-51, a potent and selective, dual P2X(3)/P2X(2/3) antagonist for the treatment of pain. [electronic resource]
Producer: 20090820Description: 1632-5 p. digitalISSN:- 1464-3405
- Adenosine Triphosphate -- chemistry
- Analgesics -- chemical synthesis
- Animals
- CHO Cells
- Chemistry, Pharmaceutical -- methods
- Cricetinae
- Cricetulus
- Drug Design
- Drug Evaluation, Preclinical
- Humans
- Inhibitory Concentration 50
- Models, Chemical
- Pain -- drug therapy
- Purinergic P2 Receptor Antagonists
- Pyrimidines -- chemical synthesis
- Receptors, Purinergic P2 -- chemistry
- Structure-Activity Relationship
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Publication Type: Journal Article
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