Thresholds of O6-alkylguanine-DNA alkyltransferase which confer significant resistance of human glial tumor xenografts to treatment with 1,3-bis(2-chloroethyl)-1-nitrosourea or temozolomide. [electronic resource]
Producer: 20010607Description: 421-8 p. digitalISSN:- 1078-0432
- Animals
- Antineoplastic Agents, Alkylating -- therapeutic use
- Antineoplastic Combined Chemotherapy Protocols
- Apoptosis
- Carmustine -- therapeutic use
- Dacarbazine -- analogs & derivatives
- Deoxyguanosine -- analogs & derivatives
- Drug Resistance, Neoplasm
- Enzyme Inhibitors -- therapeutic use
- Glioma -- drug therapy
- Guanine -- analogs & derivatives
- Humans
- Mice
- Mice, Nude
- O(6)-Methylguanine-DNA Methyltransferase -- antagonists & inhibitors
- Temozolomide
- Transplantation, Heterologous
- Tumor Cells, Cultured
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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