The effects of single- and multiple-dose administration of bococizumab (RN316/PF-04950615), a humanized IgG2Δa monoclonal antibody binding proprotein convertase subtilisin/kexin type 9, in hypercholesterolemic subjects treated with and without atorvastatin: Results from four phase I studies. [electronic resource]
Producer: 20180827ISSN:- 1755-5922
- Administration, Intravenous
- Adult
- Aged
- Antibodies, Monoclonal, Humanized -- administration & dosage
- Anticholesteremic Agents -- administration & dosage
- Atorvastatin -- administration & dosage
- Biomarkers -- blood
- Cholesterol, LDL -- blood
- Down-Regulation
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- administration & dosage
- Hypercholesterolemia -- blood
- Male
- Middle Aged
- PCSK9 Inhibitors
- Proprotein Convertase 9 -- metabolism
- Serine Proteinase Inhibitors -- administration & dosage
- Time Factors
- Treatment Outcome
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Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial
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