The biologically crucial C terminus of cholecystokinin and the non-peptide agonist SR-146,131 share a common binding site in the human CCK1 receptor. Evidence for a crucial role of Met-121 in the activation process. [electronic resource]
Producer: 20020401Description: 7546-55 p. digitalISSN:- 0021-9258
- Amino Acid Sequence
- Amino Acids -- chemistry
- Animals
- Binding Sites
- COS Cells
- Cholecystokinin -- chemistry
- Dose-Response Relationship, Drug
- Humans
- Indoles -- chemistry
- Kinetics
- Ligands
- Methionine -- chemistry
- Models, Chemical
- Models, Molecular
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Phenylalanine -- chemistry
- Protein Binding
- Protein Structure, Tertiary
- Receptor, Cholecystokinin A
- Receptors, Cholecystokinin -- agonists
- Thiazoles -- chemistry
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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