Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2. [electronic resource]
Producer: 20080811Description: 377-83 p. digitalISSN:- 1469-221X
- Animals
- Basic Helix-Loop-Helix Transcription Factors -- metabolism
- Cell Differentiation -- physiology
- Chromatin Immunoprecipitation
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p57 -- metabolism
- DNA Primers -- genetics
- Gene Expression Regulation -- genetics
- Goblet Cells -- cytology
- Homeodomain Proteins -- metabolism
- Immunohistochemistry
- Mice
- Mice, Mutant Strains
- Receptor, Notch1 -- metabolism
- Receptor, Notch2 -- metabolism
- Stem Cells -- cytology
- Transcription Factor HES-1
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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