In vitro nucleotide misinsertion opposite the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin and DNA synthesis past the lesions using Escherichia coli DNA polymerase I (Klenow fragment). [electronic resource]
Producer: 20030206Description: 15304-14 p. digitalISSN:- 0006-2960
- Base Pair Mismatch
- DNA Damage
- DNA Polymerase I -- chemistry
- DNA Primers -- biosynthesis
- DNA, Bacterial -- chemical synthesis
- Deoxyribonucleotides -- chemical synthesis
- Escherichia coli Proteins -- chemistry
- Guanidines -- chemistry
- Guanine -- analogs & derivatives
- Guanosine -- analogs & derivatives
- Hot Temperature
- Iridium -- chemistry
- Kinetics
- Mutagenesis, Site-Directed
- Nucleic Acid Denaturation
- Nucleic Acid Heteroduplexes -- chemistry
- Oxidants -- chemistry
- Oxidation-Reduction
- Spectrophotometry, Ultraviolet
- Spiro Compounds -- chemistry
- Templates, Genetic
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
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