Discovery of MK-8970: an acetal carbonate prodrug of raltegravir with enhanced colonic absorption. [electronic resource]
Producer: 20150929Description: 245-52 p. digitalISSN:- 1860-7187
- Acetals -- chemistry
- Animals
- Area Under Curve
- Carbonates -- chemistry
- Dogs
- Drug Evaluation, Preclinical
- HIV Integrase -- chemistry
- HIV Integrase Inhibitors -- chemical synthesis
- HIV-1 -- enzymology
- Half-Life
- Hepatocytes -- metabolism
- Humans
- Intestinal Mucosa -- metabolism
- Male
- Oxadiazoles -- chemical synthesis
- Prodrugs -- chemical synthesis
- Pyrimidinones -- chemical synthesis
- Pyrrolidinones -- chemistry
- ROC Curve
- Raltegravir Potassium
- Rats
- Rats, Wistar
- Structure-Activity Relationship
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Publication Type: Journal Article
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