The carcinogen cadmium elevates CpG-demethylation and enrichment of NFYA and E2F1 in the promoter of oncogenic PRMT5 and EZH2 methyltransferases resulting in their elevated expression in vitro. [electronic resource]
Producer: 20200305Description: 125186 p. digitalISSN:- 1879-1298
- CCAAT-Binding Factor -- drug effects
- Cadmium -- metabolism
- Cell Survival -- drug effects
- CpG Islands
- DNA Methylation -- drug effects
- E2F1 Transcription Factor -- drug effects
- Enhancer of Zeste Homolog 2 Protein -- drug effects
- HEK293 Cells
- Humans
- MCF-7 Cells
- Methyltransferases -- drug effects
- Promoter Regions, Genetic -- drug effects
- Protein-Arginine N-Methyltransferases -- drug effects
- Transcription Factors -- metabolism
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Publication Type: Journal Article
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