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Orally-effective, long-acting sorbitol dehydrogenase inhibitors: synthesis, structure-activity relationships, and in vivo evaluations of novel heterocycle-substituted piperazino-pyrimidines. [electronic resource] by
- Chu-Moyer, Margaret Y
- Ballinger, William E
- Beebe, David A
- Berger, Richard
- Coutcher, James B
- Day, Wesley W
- Li, Jiancheng
- Mylari, Banavara L
- Oates, Peter J
- Weekly, R Matthew
Producer: 20020207
In:
Journal of medicinal chemistry vol. 45
Availability: No items available.
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8.
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A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners. [electronic resource] by
- Mylari, Banavara L
- Armento, Sandra J
- Beebe, David A
- Conn, Edward L
- Coutcher, James B
- Dina, Michael S
- O'Gorman, Melissa T
- Linhares, Michael C
- Martin, William H
- Oates, Peter J
- Tess, David A
- Withbroe, Gregory J
- Zembrowski, William J
Producer: 20051128
In:
Journal of medicinal chemistry vol. 48
Availability: No items available.
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9.
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A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one. [electronic resource] by
- Mylari, Banavara L
- Armento, Sandra J
- Beebe, David A
- Conn, Edward L
- Coutcher, James B
- Dina, Michael S
- O'Gorman, Melissa T
- Linhares, Michael C
- Martin, William H
- Oates, Peter J
- Tess, David A
- Withbroe, Gregory J
- Zembrowski, William J
Producer: 20030711
In:
Journal of medicinal chemistry vol. 46
Availability: No items available.
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Pyridones as glucokinase activators: identification of a unique metabolic liability of the 4-sulfonyl-2-pyridone heterocycle. [electronic resource] by
- Pfefferkorn, Jeffrey A
- Lou, Jihong
- Minich, Martha L
- Filipski, Kevin J
- He, Mingying
- Zhou, Ru
- Ahmed, Syed
- Benbow, John
- Perez, Angel-Guzman
- Tu, Meihua
- Litchfield, John
- Sharma, Raman
- Metzler, Karen
- Bourbonais, Francis
- Huang, Cong
- Beebe, David A
- Oates, Peter J
Producer: 20090821
In:
Bioorganic & medicinal chemistry letters vol. 19
Availability: No items available.
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11.
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X-ray crystallographic and kinetic studies of human sorbitol dehydrogenase. [electronic resource] by
- Pauly, Thomas A
- Ekstrom, Jennifer L
- Beebe, David A
- Chrunyk, Boris
- Cunningham, David
- Griffor, Matthew
- Kamath, Ajith
- Lee, S Edward
- Madura, Rebecca
- Mcguire, Dewitt
- Subashi, Timothy
- Wasilko, David
- Watts, Paul
- Mylari, Banavara L
- Oates, Peter J
- Adams, Paul D
- Rath, Virginia L
Producer: 20040609
In:
Structure (London, England : 1993) vol. 11
Availability: No items available.
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12.
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1-((3S,4S)-4-amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes. [electronic resource] by
- Andrews, Kim M
- Beebe, David A
- Benbow, John W
- Boyer, David A
- Doran, Shawn D
- Hui, Yu
- Liu, Shenping
- McPherson, R Kirk
- Neagu, Constantin
- Parker, Janice C
- Piotrowski, David W
- Schneider, Steven R
- Treadway, Judith L
- VanVolkenberg, Maria A
- Zembrowski, William J
Producer: 20110705
In:
Bioorganic & medicinal chemistry letters vol. 21
Availability: No items available.
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13.
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Spirolactam-based acetyl-CoA carboxylase inhibitors: toward improved metabolic stability of a chromanone lead structure. [electronic resource] by
- Griffith, David A
- Dow, Robert L
- Huard, Kim
- Edmonds, David J
- Bagley, Scott W
- Polivkova, Jana
- Zeng, Dongxiang
- Garcia-Irizarry, Carmen N
- Southers, James A
- Esler, William
- Amor, Paul
- Loomis, Kathrine
- McPherson, Kirk
- Bahnck, Kevin B
- Préville, Cathy
- Banks, Tereece
- Moore, Dianna E
- Mathiowetz, Alan M
- Menhaji-Klotz, Elnaz
- Smith, Aaron C
- Doran, Shawn D
- Beebe, David A
- Dunn, Matthew F
Producer: 20131111
In:
Journal of medicinal chemistry vol. 56
Availability: No items available.
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14.
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Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK). [electronic resource] by
- Huard, Kim
- Ahn, Kay
- Amor, Paul
- Beebe, David A
- Borzilleri, Kris A
- Chrunyk, Boris A
- Coffey, Steven B
- Cong, Yang
- Conn, Edward L
- Culp, Jeffrey S
- Dowling, Matthew S
- Gorgoglione, Matthew F
- Gutierrez, Jemy A
- Knafels, John D
- Lachapelle, Erik A
- Pandit, Jayvardhan
- Parris, Kevin D
- Perez, Sylvie
- Pfefferkorn, Jeffrey A
- Price, David A
- Raymer, Brian
- Ross, Trenton T
- Shavnya, Andre
- Smith, Aaron C
- Subashi, Timothy A
- Tesz, Gregory J
- Thuma, Benjamin A
- Tu, Meihua
- Weaver, John D
- Weng, Yan
- Withka, Jane M
- Xing, Gang
- Magee, Thomas V
Producer: 20171016
In:
Journal of medicinal chemistry vol. 60
Availability: No items available.
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