Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. [electronic resource]
Producer: 20110517Description: 1174-82 p. digitalISSN:- 1476-5594
- AMP-Activated Protein Kinases
- Animals
- Antineoplastic Agents -- pharmacology
- Blotting, Western
- Carcinoma, Lewis Lung
- Diet
- Drug Resistance, Neoplasm -- genetics
- Genes, Tumor Suppressor
- Hyperinsulinism -- drug therapy
- Hypoglycemic Agents -- pharmacology
- Male
- Metformin -- pharmacology
- Mice
- Mice, Inbred C57BL
- Neoplasms, Experimental -- drug therapy
- Protein Serine-Threonine Kinases -- genetics
- Signal Transduction -- drug effects
- Transfection
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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