Cytotoxic T-lymphocyte clones, established by stimulation with the HLA-A2 binding p5365-73 wild type peptide loaded on dendritic cells In vitro, specifically recognize and lyse HLA-A2 tumour cells overexpressing the p53 protein. [electronic resource]
Producer: 20000315Description: 128-33 p. digitalISSN:- 0300-9475
- Cell Line, Transformed
- Cells, Cultured
- Clone Cells
- Coculture Techniques
- Cytotoxicity, Immunologic -- immunology
- Dendritic Cells -- immunology
- Gene Expression
- HLA-A2 Antigen -- immunology
- Humans
- K562 Cells
- Male
- Mutation
- Peptides -- immunology
- Receptors, Antigen, T-Cell -- genetics
- T-Lymphocytes, Cytotoxic -- cytology
- Tumor Cells, Cultured
- Tumor Suppressor Protein p53 -- biosynthesis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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