Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity. [electronic resource]
Producer: 20170814Description: 4424-4432 p. digitalISSN:- 1464-3391
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- chemical synthesis
- Arachidonic Acid
- Carrageenan
- Cyclooxygenase Inhibitors -- chemical synthesis
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Design
- Edema -- chemically induced
- Female
- Indolizines -- chemical synthesis
- Lipoxygenase -- metabolism
- Lipoxygenase Inhibitors -- chemical synthesis
- Male
- Mice
- Molecular Structure
- Prostaglandin-Endoperoxide Synthases -- metabolism
- Rats
- Structure-Activity Relationship
- Ulcer -- chemically induced
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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