Preclinical in vivo evaluation of rapamycin in human malignant peripheral nerve sheath explant xenograft. [electronic resource]
Producer: 20100113Description: 563-71 p. digitalISSN:- 1097-0215
- Animals
- Antibiotics, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Blotting, Western
- Cyclin D1 -- metabolism
- Dose-Response Relationship, Drug
- Drug Evaluation, Preclinical
- Humans
- Immunohistochemistry
- Male
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Neurofibromatosis 1 -- drug therapy
- Peripheral Nervous System Neoplasms -- drug therapy
- Protein Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Ribosomal Protein S6 Kinases -- metabolism
- Signal Transduction -- drug effects
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases
- Tumor Burden -- drug effects
- Vascular Endothelial Growth Factor A -- metabolism
- Xenograft Model Antitumor Assays
- Young Adult
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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