Acetylshikonin induces apoptosis of human leukemia cell line K562 by inducing S phase cell cycle arrest, modulating ROS accumulation, depleting Bcr-Abl and blocking NF-κB signaling. [electronic resource]
Producer: 20200929Description: 109677 p. digitalISSN:- 1950-6007
- Animals
- Anthraquinones -- pharmacology
- Apoptosis -- drug effects
- Apoptosis Regulatory Proteins -- metabolism
- Cell Cycle -- drug effects
- Cell Line
- Cell Proliferation -- drug effects
- Chlorocebus aethiops
- Fusion Proteins, bcr-abl -- metabolism
- Humans
- K562 Cells
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive -- drug therapy
- Mitochondria -- drug effects
- Protein Serine-Threonine Kinases -- metabolism
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Vero Cells
- NF-kappaB-Inducing Kinase
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Publication Type: Journal Article
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