Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity. [electronic resource]
Producer: 20210216Description: 207-225 p. digitalISSN:- 1420-9071
- 3-Hydroxysteroid Dehydrogenases -- antagonists & inhibitors
- Binding Sites
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cholesterol -- chemistry
- Crystallography, X-Ray
- Enzyme Inhibitors -- chemistry
- ErbB Receptors -- antagonists & inhibitors
- Erlotinib Hydrochloride -- chemistry
- Humans
- Kinetics
- Molecular Docking Simulation
- Mutagenesis, Site-Directed
- NAD -- chemistry
- Protein Structure, Tertiary
- Recombinant Proteins -- biosynthesis
- Signal Transduction
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Publication Type: Journal Article
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