HTLV-I infection of WE17/10 CD4+ cell line leads to progressive alteration of Ca2+ influx that eventually results in loss of CD7 expression and activation of an antiapoptotic pathway involving AKT and BAD which paves the way for malignant transformation. [electronic resource]
Producer: 20070928Description: 788-96 p. digitalISSN:- 0887-6924
- Antigens, CD7 -- genetics
- Apoptosis
- CD4-Positive T-Lymphocytes -- drug effects
- Calcium Signaling -- physiology
- Cell Line
- Cell Transformation, Neoplastic
- Flow Cytometry
- Gene Expression Regulation, Viral
- HTLV-I Infections -- physiopathology
- Humans
- Ionomycin -- pharmacology
- Oncogene Protein v-akt -- genetics
- RNA -- genetics
- Reverse Transcriptase Polymerase Chain Reaction
- bcl-Associated Death Protein -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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