Combinatorial antitumor effect of HDAC and the PI3K-Akt-mTOR pathway inhibition in a Pten defecient model of prostate cancer. [electronic resource]
Producer: 20141112Description: 2225-36 p. digitalISSN:- 1949-2553
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Cell Proliferation -- drug effects
- DNA Damage
- Histone Deacetylase Inhibitors -- administration & dosage
- Humans
- Hydroxamic Acids -- administration & dosage
- Imidazoles -- administration & dosage
- Indoles -- administration & dosage
- Male
- Mice
- Mice, SCID
- Oncogene Protein v-akt -- antagonists & inhibitors
- PTEN Phosphohydrolase -- deficiency
- Panobinostat
- Phosphatidylinositol 3-Kinases -- genetics
- Phosphoinositide-3 Kinase Inhibitors
- Prostatic Neoplasms, Castration-Resistant -- drug therapy
- Quinolines -- administration & dosage
- Random Allocation
- Signal Transduction -- drug effects
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
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