Analysis of the most representative tumour-derived p53 mutants reveals that changes in protein conformation are not correlated with loss of transactivation or inhibition of cell proliferation. [electronic resource]
Producer: 19940921Description: 3496-504 p. digitalISSN:- 0261-4189
- Animals
- Antibodies, Monoclonal
- Arginine -- genetics
- CHO Cells
- Cell Division
- Cell Line
- Cell Nucleus -- chemistry
- Codon -- genetics
- Cricetinae
- Cytoplasm -- chemistry
- Dinucleoside Phosphates
- Genes, jun -- genetics
- Genes, p53 -- genetics
- Heat-Shock Proteins -- metabolism
- Humans
- Mutagenesis, Site-Directed
- Point Mutation -- physiology
- Protein Conformation
- Transcriptional Activation
- Tumor Suppressor Protein p53 -- analysis
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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