Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3. [electronic resource]
Producer: 20140225Description: e655 p. digitalISSN:- 2041-4889
- Animals
- Antineoplastic Agents -- pharmacology
- Cell Line, Tumor
- Cell Survival -- drug effects
- Drug Synergism
- Gene Knockdown Techniques
- Histone Deacetylase Inhibitors -- pharmacology
- Humans
- Hydroxamic Acids -- pharmacology
- Indoles -- pharmacology
- Male
- Melanoma -- drug therapy
- Mice
- Mice, Nude
- Mutation, Missense
- Necrosis
- Panobinostat
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- RNA, Small Interfering -- genetics
- Receptor-Interacting Protein Serine-Threonine Kinases -- genetics
- Sulfonamides -- pharmacology
- Vemurafenib
- Vorinostat
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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