Novel mechanism of reducing tumourigenesis: upregulation of the DNA repair enzyme OGG1 by rapamycin-mediated AMPK activation and mTOR inhibition. [electronic resource]
Producer: 20110119Description: 2806-20 p. digitalISSN:- 1879-0852
- AMP-Activated Protein Kinase Kinases
- Animals
- Antibiotics, Antineoplastic -- pharmacology
- DNA Glycosylases -- metabolism
- DNA Repair Enzymes -- metabolism
- Drug Screening Assays, Antitumor
- Epithelial Cells
- Humans
- Immunoblotting
- Kidney Neoplasms -- drug therapy
- Kidney Tubules, Proximal
- Male
- Mice
- Protein Kinases -- metabolism
- Sirolimus -- pharmacology
- TOR Serine-Threonine Kinases -- antagonists & inhibitors
- Tumor Cells, Cultured
- Up-Regulation
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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