A single point mutation in the low-density lipoprotein receptor switches the degradation of its mature protein from the proteasome to the lysosome. [electronic resource]
Producer: 20060905Description: 1340-51 p. digitalISSN:- 1357-2725
- Acetylcysteine -- analogs & derivatives
- Animals
- Binding, Competitive -- drug effects
- Biological Transport -- drug effects
- CHO Cells
- COS Cells
- Chlorocebus aethiops
- Cricetinae
- Cricetulus
- Cysteine Proteinase Inhibitors -- pharmacology
- Humans
- Lipoproteins, LDL -- metabolism
- Lysosomes -- metabolism
- Mutant Proteins -- genetics
- Point Mutation
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors
- Protein Processing, Post-Translational
- Receptors, LDL -- genetics
- Signal Transduction -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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