New alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey. [electronic resource]
Producer: 20041221Description: 327-36 p. digitalISSN:- 0969-8051
- ATP Binding Cassette Transporter, Subfamily B, Member 1 -- deficiency
- Adrenergic alpha-1 Receptor Antagonists
- Animals
- Antipsychotic Agents -- chemistry
- Brain -- diagnostic imaging
- Caco-2 Cells
- Carbon Radioisotopes -- chemistry
- Cyclosporine -- pharmacology
- Drug Evaluation, Preclinical
- Humans
- Imidazoles -- chemistry
- Indoles -- chemistry
- Isotope Labeling -- methods
- Kinetics
- Macaca fascicularis
- Male
- Metabolic Clearance Rate
- Mice
- Positron-Emission Tomography -- methods
- Protein Binding
- Radiopharmaceuticals -- chemical synthesis
- Receptors, Adrenergic, alpha-1 -- metabolism
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Publication Type: Comparative Study; Evaluation Study; Journal Article
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