Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. [electronic resource]
Producer: 20050405Description: 7707-17 p. digitalISSN:- 1529-2401
- Aging
- Alzheimer Disease
- Amyloid Precursor Protein Secretases
- Amyloid beta-Peptides -- toxicity
- Amyloid beta-Protein Precursor -- genetics
- Animals
- Apoptosis
- Aspartic Acid Endopeptidases
- Carrier Proteins -- metabolism
- Endopeptidases -- metabolism
- Hippocampus -- cytology
- Humans
- Insulin-Like Growth Factor II -- biosynthesis
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Models, Animal
- Nerve Degeneration -- genetics
- Nerve Tissue Proteins -- biosynthesis
- Organ Culture Techniques
- Peptide Fragments -- toxicity
- Phosphorylation
- PrPC Proteins -- genetics
- Prealbumin -- antagonists & inhibitors
- Promoter Regions, Genetic
- Protease Nexins
- Protein Processing, Post-Translational -- drug effects
- RNA, Small Interfering -- pharmacology
- Receptors, Cell Surface -- genetics
- Transgenes
- bcl-Associated Death Protein
- tau Proteins -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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