Autoantibodies to variable heavy (VH) chain Ig sequences in humans impact the safety and clinical pharmacology of a VH domain antibody antagonist of TNF-α receptor 1. [electronic resource]
Producer: 20140423Description: 1192-203 p. digitalISSN:- 1573-2592
- Adolescent
- Adult
- Aged
- Antibodies, Monoclonal -- administration & dosage
- Autoantibodies -- metabolism
- Biomarkers, Pharmacological -- metabolism
- Female
- Humans
- Immunoglobulin Heavy Chains -- immunology
- Immunoglobulin Variable Region -- immunology
- Male
- Middle Aged
- Molecular Targeted Therapy
- Pharmacology, Clinical
- Prospective Studies
- Receptors, Tumor Necrosis Factor, Type I -- immunology
- Signal Transduction
- Young Adult
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Publication Type: Journal Article; Randomized Controlled Trial
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