Simvastatin prevents isoproterenol-induced cardiac hypertrophy through modulation of the JAK/STAT pathway. [electronic resource]
Producer: 20160329Description: 3217-29 p. digitalISSN:- 1177-8881
- Animals
- Biomarkers -- blood
- Cardiomegaly -- blood
- Creatine Kinase, MB Form -- blood
- Cytoprotection
- Disease Models, Animal
- Fibrosis
- Hydroxymethylglutaryl-CoA Reductase Inhibitors -- pharmacology
- Interleukin-6 -- blood
- Isoproterenol
- Janus Kinases -- metabolism
- Lipids -- blood
- Male
- Myocytes, Cardiac -- drug effects
- NF-kappa B -- metabolism
- Phosphorylation
- Rats, Wistar
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Simvastatin -- pharmacology
- Troponin I -- blood
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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