Molecular mechanisms of cardiotoxicity of gefitinib in vivo and in vitro rat cardiomyocyte: Role of apoptosis and oxidative stress. [electronic resource]
Producer: 20170131Description: 50-61 p. digitalISSN:- 1879-3169
- Animals
- Antineoplastic Agents -- toxicity
- Apoptosis -- drug effects
- Cardiomegaly -- chemically induced
- Cardiotoxicity
- Caspase 3 -- genetics
- Cell Line
- Dose-Response Relationship, Drug
- Gefitinib
- Gene Expression Regulation -- drug effects
- Heme Oxygenase (Decyclizing) -- genetics
- Male
- Myocytes, Cardiac -- drug effects
- Oxidative Stress -- drug effects
- Protein Kinase Inhibitors -- toxicity
- Quinazolines -- toxicity
- Rats, Wistar
- Reactive Oxygen Species -- metabolism
- Signal Transduction -- drug effects
- Tumor Suppressor Protein p53 -- genetics
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Publication Type: Journal Article
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